Gene information
Official symbol HLA-DRB1
Official full name major histocompatibility complex, class II, DR beta 1
Gene type protein-coding gene
Chromosome6p21.32
Previous symbolHLA-DR1B
Gene familyHistocompatibility complex; C1-set domain containing
Resources
Entrez Gene 3123
HGNC HGNC:4948
Ensembl ENSG00000196126
Vega OTTHUMG00000031196
UCSC uc003obp.5
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO Biological Processes -3.17989306 9 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002573 myeloid leukocyte differentiation GO Biological Processes -7.83519790 12 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002764 immune response-regulating signaling pathway GO Biological Processes -3.80325753 14 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002861 regulation of inflammatory response to antigenic stimulus GO Biological Processes -5.72585157 11 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005774 vacuolar membrane GO Cellular Components -1.32038132 10 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009595 detection of biotic stimulus GO Biological Processes -6.46280795 7 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030099 myeloid cell differentiation GO Biological Processes -6.71806250 15 More
GO:0030134 COPII-coated ER to Golgi transport vesicle GO Cellular Components -3.04449021 6 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030136 clathrin-coated vesicle GO Cellular Components -3.00394155 9 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030247 polysaccharide binding GO Molecular Functions -3.31496494 6 More
GO:0030662 coated vesicle membrane GO Cellular Components -3.21530675 9 More
GO:0030665 clathrin-coated vesicle membrane GO Cellular Components -2.98664168 7 More
GO:0030666 endocytic vesicle membrane GO Cellular Components -7.03002758 14 More
GO:0030669 clathrin-coated endocytic vesicle membrane GO Cellular Components -4.62709399 7 More
GO:0031343 positive regulation of cell killing GO Biological Processes -3.44182824 10 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032024 positive regulation of insulin secretion GO Biological Processes -3.33317104 10 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032689 negative regulation of interferon-gamma production GO Biological Processes -6.05054543 11 More
GO:0032945 negative regulation of mononuclear cell proliferation GO Biological Processes -3.06905273 11 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0042277 peptide binding GO Molecular Functions -10.2245210 22 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.04470175 15 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043903 regulation of biological process involved in symbiotic interaction GO Biological Processes -3.29518609 9 More
GO:0045334 clathrin-coated endocytic vesicle GO Cellular Components -4.88495680 8 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045582 positive regulation of T cell differentiation GO Biological Processes -5.99210992 10 More
GO:0045589 regulation of regulatory T cell differentiation GO Biological Processes -3.16741146 4 More
GO:0045655 regulation of monocyte differentiation GO Biological Processes -2.92503639 5 More
GO:0046634 regulation of alpha-beta T cell activation GO Biological Processes -7.20313216 11 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048524 positive regulation of viral process GO Biological Processes -2.4114088 8 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0050672 negative regulation of lymphocyte proliferation GO Biological Processes -2.56497893 10 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050792 regulation of viral process GO Biological Processes -4.90676471 20 More
GO:0050796 regulation of insulin secretion GO Biological Processes -13.8348879 19 More
GO:0050852 T cell receptor signaling pathway GO Biological Processes -1.46333334 4 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050868 negative regulation of T cell activation GO Biological Processes -5.59075646 10 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051606 detection of stimulus GO Biological Processes -2.56190637 17 More
GO:0052372 modulation by symbiont of entry into host GO Biological Processes -2.32945221 7 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO Biological Processes -2.97443173 8 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070664 negative regulation of leukocyte proliferation GO Biological Processes -3.96184640 13 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098581 detection of external biotic stimulus GO Biological Processes -6.40916397 6 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1903900 regulation of viral life cycle GO Biological Processes -3.59662203 16 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04658 Th1 and Th2 cell differentiation KEGG Pathway -5.18694144 15 More
hsa05140 Leishmaniasis KEGG Pathway -12.4439861 14 More
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05310 Asthma KEGG Pathway -7.19451595 7 More
hsa05320 Autoimmune thyroid disease KEGG Pathway -5.52369866 7 More
hsa05332 Graft-versus-host disease KEGG Pathway -5.01134628 6 More
Drug-Gene interaction
view
Related drugs: 31 records
Drug name Interaction type Source PMID View
adalimumab PharmGKB view
amoxicillin PharmGKB 208009211053588230664875 view
asparaginase PharmGKB 2497093225987655 view
aspirin PharmGKB 1578411319392989 view
atorvastatin PharmGKB 27839692 view
azathioprine PharmGKB 25217962 view
bucillamine PharmGKB view
carbamazepine PharmGKB 2439972123830818 view
carbimazole PharmGKB view
clavulanic acid PharmGKB 208009211053588230664875 view
dabrafenib PharmGKB 27023328 view
dapsone PharmGKB 29233746 view
efavirenz PharmGKB 18301070 view
etanercept PharmGKB view
floxacillin PharmGKB 30664875 view
flupirtine PharmGKB 26959717 view
fluvastatin PharmGKB 27839692 view
infliximab PharmGKB view
lamotrigine PharmGKB 19668019 view
lapatinib PharmGKBFDA 2468783028786423 view
lumiracoxib PharmGKB 20639878 view
lym-1 ChemblInteractionsTTD view
mercaptopurine PharmGKB 25217962 view
methimazole PharmGKB view
oxcarbazepine PharmGKB 27666425 view
pitavastatin PharmGKB 27839692 view
pravastatin PharmGKB 27839692 view
propylthiouracil PharmGKB view
rosuvastatin PharmGKB 27839692 view
simvastatin PharmGKB 27839692 view
ticlopidine PharmGKB 17339877 view
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
HLA-DRB1*01 genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Paakkanen R et al. Atherosclerosis. 2012
HLA-DQA1*02 genomics acute myocardial infarction[diagnosis] acute myocardial infarction Bjorkbacka H et al. J Intern Med. 2010
HLA-DRB1*0101 genomics acute myocardial infarction[diagnosis] acute myocardial infarction Bjorkbacka H et al. J Intern Med. 2010
HLA-DRB1*07 genomics acute myocardial infarction[diagnosis] acute myocardial infarction Bjorkbacka H et al. J Intern Med. 2010
All rights reserved: Soochow University Center for Systems Biology